ChemiSCREEN™ PRP/GPR10 Prolactin Releasing Peptide Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ PRP/GPR10 Prolactin Releasing Peptide Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prolactin releasing peptide) based activation of PRLHR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses PRLHR alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of PRLHR , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Prolactin-Releasing Peptide

Sub Family:

Class A

Protein Name:

PRP

Protein Aliases:

PrRPR|G-protein coupled receptor 10|hGR3

Accession Number:

NM_004248

UniProt Number:

P49683

Gene Name:

PRLHR

Gene ID:

2834

Gene Aliases:

PrRPR

Target Species:

Human

Cell Background:

Chem-1