ChemiSCREEN™ OXGR1 alpha-Ketoglutarate Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ OXGR1 α-Ketoglutarate Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. α-ketoglutarate) based activation of OXGR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses OXGR1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of OXGR1 , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Oxoglutarate

Sub Family:

Class A

Protein Name:

OXGR1 (GPR99 )

Protein Aliases:

2-oxoglutarate receptor 1|alpha-ketoglutarate receptor 1

Accession Number:

NM_080818.3

UniProt Number:

Q96P68

Gene Name:

OXGR1

Gene ID:

27199

Gene Aliases:

P2RY15|P2Y15|aKGR

Target Species:

Human

Cell Background:

Chem-1