ChemiSCREEN™ NPBW1 Neuropeptide B/W Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ NPBW1 Neuropeptide B/W Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. neuropeptide B/W) based activation of NPBWR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses NPBWR1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of NPBWR1 , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Neuropeptide W / Neuropeptide B

Sub Family:

Class A

Protein Name:

NPBW1

Accession Number:

NM_005285

UniProt Number:

P48145

Gene Name:

NPBWR1

Gene ID:

2831

Gene Aliases:

GPR7

Target Species:

Human

Cell Background:

Chem-4