ChemiSCREEN™ NMU1 Neuromedin U Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ NMU1 Neuromedin U Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. Neuromedin U) based activation of NMU1R GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses NMU1R alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of NMU1R , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Neuromedin U

Sub Family:

Class A

Protein Name:

NMU1

Protein Aliases:

G-protein coupled receptor 66|G-protein coupled receptor FM-3

Accession Number:

NM_006056

UniProt Number:

Q9HB89

Gene Name:

NMUR1

Gene ID:

10316

Gene Aliases:

GPC-R|FM-3|NMU1R

Target Species:

Human

Cell Background:

Chem-1