ChemiScreen™ C3aR Anaphylotoxin Receptor Stable Cell Line

The ChemiScreen™ C3aR Anaphylotoxin Receptor Stable Cell Line measures C3AR1 (GPCR) activation via an increase in intracellular calcium. This cell line ships as two vials of cryopreserved cells.

Catalog #: HTS016C Size: 2 vials
Biological Information
Background Information:
The ChemiScreen™ C3aR Anaphylotoxin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. C3a) based activation of C3AR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses C3AR1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of C3AR1 , the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:
Complement Peptide Receptor (Anaphylotoxin)
Accession Number:
Target Name:
C3AR1 (C3a receptor)
Target Aliases:
Complement component 3a receptor 1, C3AR1, C3A, Complement Peptide (Anaphylatoxin)
Target Species:
Product Type:
Stable Cell Lines
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage Disclaimer:
These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Measures:
Calcium Flux
Detection Method:
Additional Information

User Manuals & Protocols

70-427 ChemiSCREEN and ChemiBRITE Cell Lines User Manual REV1

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HTS016C Datasheet

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