The ChemiScreen™ BLT1 Leukotriene Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. leukotriene) based activation of LTB4R GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses LTB4R alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of LTB4R , the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells.
Leukotriene B4 receptor, BLT1, BLTR, CMKRL1, GPR16, LTBR1, P2RY7, P2Y7, LTB4R
Stable Cell Lines
Drug Discovery & Development
Store in vapor phase of liquid nitrogen.
These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
ChemiScreen™ BLT1 Leukotriene Receptor Stable Cell Line
The ChemiScreen™ BLT1 Leukotriene Receptor Stable Cell Line measures LTB4R (GPCR) activation via an increase in intracellular calcium. This cell line ships as two vials of cryopreserved cells.