ChemiScreen™ BB3 Bombesin Receptor Stable Cell Line

The ChemiScreen™ BB3 Bombesin Receptor Stable Cell Line measures BRS3 (GPCR) activation via an increase in intracellular calcium. This cell line ships as two vials of cryopreserved cells.

Catalog #: HTS160C Size: 2 vials
Biological Information
Background Information:
The ChemiScreen™ BB3 Bombesin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. bombesin) based activation of BRS3 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses BRS3 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of BRS3 , the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:
Bombesin Receptor
Accession Number:
Target Name:
BRS3 (BB3 Receptor)
Target Aliases:
Bombesin receptor, subtype 3, BRS3, BB3, Bombesin
Target Species:
Product Type:
Stable Cell Lines
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage Disclaimer:
These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Measures:
Calcium Flux
Detection Method:
Additional Information

User Manuals & Protocols

70-427 ChemiSCREEN and ChemiBRITE Cell Lines User Manual REV1

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HTS160C Datasheet

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