ChemiSCREEN™ 5-HT6 Serotonin Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ 5-HT6 Serotonin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. serotonin/5-HT) based activation of HTR6 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses HTR6 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of HTR6 , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Serotonin

Sub Family:

Class A

Protein Name:

5-HT6

Protein Aliases:

5-HT6|Serotonin receptor 6

Accession Number:

NM_000871

UniProt Number:

P50406

Gene Name:

HTR6

Gene ID:

3362

Gene Aliases:

5-HT6|5-HT6R

Target Species:

Human

Cell Background:

Chem-10