| Biological Information | |
|---|---|
| Background Information: | Cyclin-dependent Kinase 5 (cdk5) is a cyclin-dependent serine/threonine kinase that, while not involved in cell proliferation, plays a critical role in neuron development. The kinase is activated strongly when it complexes with neuron-specific activators, especially p35, but less strongly when it complexes with cyclins. In contrast, a constitutively active form of the complex results when cdk5 binds with p25 or p21 (truncated forms of p35). The cdk5/p35 complex has been implicated in neurite outgrowth, neuronal differentiation and neuronal migration and axon patterning. The complex phosphorylates the tau protein at Ser199, Ser202 and Thr205. Hyper-phosphorylated tau will cause neurofibrillary tangles and lead to Alzheimer's disease. Research has also shown the cdk5/p35 complex is associated with drug addiction and amyotrophic lateral sclerosis. Inhibitors may prevent the progression of Alzheimer's disease, amyotrophic lateral sclerosis, and other neurodegenerative diseases.
GenBank X66364 / GenBank X80343 |
| Target Class: | Kinase |
| Family: | Serine/Threonine Kinase: CDK5 subfamily |
| Accession Number: | NM_004935.2 |
| Target Name: | CDK5/p35 |
| Target Aliases: | CDK5, PSSALRE |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 1 year at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
Cdk5/p35, active
Complex of recombinant, human full length cdk5 containing and N-terminal 6His-tag and recombinant, human full length p35 containing an N-terminal GST-tag.
Datasheets
14-477x Datasheet
View Document