CDK4/cyclin D3, active

Background Information:

CDK4 (Cyclin-dependent kinase 4) forms a complex with type D cyclins such as D1, D2 and D3 and when the cellular levels of cyclin D peak there is a shortening of the G1 phase and rapid entry into S phase of cell cycle progression. The substrate for cdk4/cyclin D is Rb, and phosphorylation of Rb results in dissociation of the E2F complex from Rb. The free E2F proteins in turn stimulate transcription of genes required for DNA synthesis. Cellular inhibition of CDK4/cyclin D3 activity is achieved by its inhibitory proteins, i.e. p16, p21 and p27. Inhibition of CDK4/CCND3 may be used in treatment of uncontrolled cell proliferation, tumor heterogeneity, invasion and metastasis. GenBank NM_000075.3 / GenBank M90814.1

Target Class:

Kinase

Family:

CMGC

Sub Family:

Protein Ser/Thr

Protein Name:

CDK4

Protein Aliases:

Cell division protein kinase 4|PSK-J3

Accession Number:

NM_000075.3

UniProt Number:

P11802

Gene Name:

CDK4

Gene ID:

1019

Gene Aliases:

PSK-J3

Target Species:

Human