Cdk3/Cyclin E, active

Background Information:

The cyclin-dependent kinases (CDKs), a subfamily of protein kinases, promote cell cycle progression. In mammals, nine different CDKs (cdk 1 to cdk 9; cdk 1 is better known as cdc 2) have been identified. CDKs are regulated on various levels including binding of proteins (cyclins, inhibitors, and assembly factors), protein degradation, transcriptional control, localization, and multiple phosphorylations. This leads to timely regulation of CDK activity, allowing progression from one cell cycle phase to the next. Cdk3 participates in the G1–S progression at least partially by binding to E2F-1, E2F-2, or E2F-3 through DP-1 and by enhancing their transcriptional activities. GenBank X66357 / GenBank NM_001238

Target Class:

Kinase

Family:

CMGC

Sub Family:

Protein Ser/Thr

Protein Name:

CDK3

Protein Aliases:

Cell division protein kinase 3

Accession Number:

NM_001258.1

UniProt Number:

Q00526

Gene Name:

CDK3

Gene ID:

1018

Target Species:

Human