Cdk2/Cyclin E, active

Background Information:

The cyclin-dependent kinases (CDKs), are a family of serine threonine protein kinases, that control the cell division cycle. In mammals, nine different CDKs (cdk 1 to cdk 9) have been identified. CDKs are regulated on various levels including binding of proteins (cyclins, inhibitors, and assembly factors), protein degradation, transcriptional control, localization, and multiple phosphorylations. This leads to timely regulation of CDK activity, allowing progression from one cell cycle phase to the next. The cdk2 promotes the G1/S transition and progression through the S phase when bound to specific cyclins (E and A). Recent evidences indicate that CDK2 is involved in cell cycle independent functions such as DNA damage repair. EMBL M68520 / GenBank NM_001238

Target Class:

Kinase

Family:

CMGC

Sub Family:

Protein Ser/Thr

Protein Name:

CDK2

Protein Aliases:

Cell division protein kinase 2|p33 protein kinase

Accession Number:

NM_001798.2; NM_052827.1

UniProt Number:

P24941

Gene Name:

CDK2

Gene ID:

1017

Target Species:

Human