| Biological Information | |
|---|---|
| Background Information: | Casein kinase 2 (CK2) is a serine/threonine protein kinase that is ubiquitously expressed in eukaryotic cells. CK2 is a heterotetrameric enzyme composed of two catalytic subunits (α and/or α') and two regulatory subunits (β). The α and α' subunits have high sequence identity and are functionally interchangeable. CK2 plays a role in many cellular processes, including cell growth, proliferation, differentiation, and apoptosis. It has been shown to regulate the activity of various transcription factors, kinases, and phosphatases. CK2 is also involved in the regulation of ion channels, membrane transporters, and the cytoskeleton.
Overexpression of CK2 has been observed in many types of cancer, and has been linked to the regulation of oncogenes and tumor suppressor genes. CK2 has also been implicated in the regulation of viral infections, and is known to be involved in the replication of several viruses, including hepatitis C virus, HIV, and human papillomavirus. |
| Target Class: | Kinase |
| Accession Number: | NM_001895.3; NM_177559.2; NM_177560.2 |
| Target Name: | CK2 |
| Target Aliases: | CSNK2A1, CK2A1, CKII |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 1 year at -20°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
Casein Kinase 2, active
Recombinant, human full length Casein Kinase 2 protein, containing an α-subunit N-terminal 6His tag and a β-subunit N-terminal GST tag.
Datasheets
14-197x Datasheet
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