| Biological Information | |
|---|---|
| Background Information: | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyper-phosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.
GenBank NM_001319 |
| Target Class: | Kinase |
| Accession Number: | NM_001319.5 |
| Target Name: | CK1γ2 |
| Target Aliases: | CSNK1G2, CK1g2 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
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Casein Kinase 1gamma2, active
N-terminal 6His-tagged recombinant, human Casein Kinase 1γ2 amino acids 18-end N-terminal 6His-tagged recombinant, human Casein Kinase 1γ2 amino acids 18-end.
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