The cAMP Hunter™ Liraglutide Bioassay kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses ligand (e.g. Liraglutide) based activation of GLP-1R GPCR activity via detection of levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type GLP-1R, a naturally Gs coupled GPCR. Upon activation of GLP-1R, the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied. This assay has been optimized and qualified with Victoza® (not supplied in the bioassay kit). Victoza® is a registered trademark of Novo Nordisk A/S. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates.
Glucagon Receptor Family
Glucagon-like peptide receptor 1, GLP-1, GLP-1-R, GLP-1R
Potency; Commercial Release & Stability
Store in vapor phase of liquid nitrogen.
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Victoza® is a registered trademark of Novo Nordisk A/S
cAMP Hunter™ Liraglutide Bioassay Kit
The cAMP Hunter™ Liraglutide Bioassay kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses ligand (e.g. Liraglutide) based activation of GLP-1R GPCR activity via detection of levels of intracellular cAMP.
View bioassay qualification data.