The cAMP Hunter™ Follitropin Alfa Bioassay kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses Follitropin Alfa based activation of FSHR GPCR activity via detection of levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type FSHR, a naturally Gs coupled GPCR. Upon activation of FSHR, the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied. This assay has been optimized and qualified with Gonal-F (not supplied in the bioassay kit). Gonal-F is a registered trademark of Merck KGAA. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates.
Glycoprotein Hormone Receptors
Follicle stimulating hormone receptor, LGR1, ODG1, FSHR1, FSHRO
Potency; Commercial Release & Stability
Store in vapor phase of liquid nitrogen.
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Gonal-f® is a registered trademark of Merck KGAA
cAMP Hunter™ Follitropin Alfa Bioassay Kit
The cAMP Hunter™ Follitropin Alfa Bioassay kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses Follitropin Alfa based activation of FSHR GPCR activity via detection of levels of intracellular cAMP.
View bioassay qualification data.