The cAMP Hunter™ LTB4R eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. leukotriene B4) based activation of LTB4R GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type LTB4R, a naturally Gi/Go coupled GPCR. Upon activation of LTB4R, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.
Leukotriene B4 receptor, BLT1, BLTR, CMKRL1, GPR16, LTBR1, P2RY7, P2Y7, LTB4R
eXpress Assay Kits
Drug Discovery & Development
Store in vapor phase of liquid nitrogen.
Ready-to-use eXpress assay kits are intended for in vitro research purposes only. These kits are not suitable for lot release applications. Refer to the ready-to-use bioassay kit format for potency testing in lot release for biologic therapeutics. These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
cAMP Hunter™ eXpress LTB4R CHO-K1 GPCR Assay
The cAMP Hunter™ eXpress LTB4R CHO-K1 GPCR Assay measures LTB4R (GPCR) activity via decreased levels of intracellular cAMP. eXpress kits contain all assay materials: cells, reagents, and plates.