cAMP Hunter™ DLD1 ADRB3 Gs Cell Line

Background Information:

The cAMP Hunter™ ADRB3 Gs cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. epinephrine and norepinephrine) based activation of ADRB3 GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type ADRB3 , a naturally Gs coupled GPCR. Upon activation of ADRB3 , the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Adrenoceptor

Sub Family:

Class A

Coupling:

Gs

Protein Name:

beta3

Protein Aliases:

Beta-3 adrenoceptor

Accession Number:

NM_000025

UniProt Number:

P13945

Gene Name:

ADRB3

Gene ID:

155

Target Species:

Human

Cell Background:

DLD1