cAMP Hunter™ CHO-K1 PTHR2 Gs Cell Line

The cAMP Hunter™ CHO-K1 PTHR2 Gs Cell Line measures PTHR2 (GPCR) activity via increased levels of intracellular cAMP. This cell line ships as two vials of cryopreserved cells.

Catalog #: 95-0057C2 Size: 2 vials

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Biological Information
Background Information:	The cAMP Hunter™ PTHR2 Gs cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. parathyroid hormone, TIP 39) based activation of PTHR2 GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type PTHR2 , a naturally Gs coupled GPCR. Upon activation of PTHR2 , the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	GPCR
Family:	Parathyroid Hormone Receptors
Sub Family:	Class B
Coupling:	Gq & Gs
Accession Number:	AY497546
Target Name:	PTHR2
Target Aliases:	Parathyroid hormone receptor 2, PTH2R, PTH2 receptor, PTHR2, parathyroid hormone 2 receptor, parathyroid hormone receptor 2
Target Species:	Human
Cell Background:	CHO-K1

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	cAMP Detection
Detection Method:	Chemiluminescence

Additional Information
Brand:	cAMP Hunter™