cAMP Hunter™ CHO-K1 OXER1 Gi Cell Line

Background Information:

The cAMP Hunter™ OXER1 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. 5-oxo-ETE) based activation of OXER1 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type OXER1 , a naturally Gi/Go coupled GPCR. Upon activation of OXER1 , the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Leukotriene

Sub Family:

Class A

Coupling:

Gi/Go

Protein Name:

OXE

Protein Aliases:

G-protein coupled receptor 170|G-protein coupled receptor R527|G-protein coupled receptor TG1019

Accession Number:

NM_148962

UniProt Number:

Q8TDS5

Gene Name:

OXER1

Gene ID:

165140

Gene Aliases:

GPCR|TG1019|GPR170

Target Species:

Human

Cell Background:

CHO-K1