cAMP Hunter™ CHO-K1 MTNR1B Gi Cell Line

Background Information:

The cAMP Hunter™ MTNR1B Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. melatonin) based activation of MTNR1B GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type MTNR1B , a naturally Gi/Go coupled GPCR. Upon activation of MTNR1B , the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Melatonin

Sub Family:

Class A

Coupling:

Gi/Go

Protein Name:

MT2

Protein Aliases:

Mel1b receptor

Accession Number:

NM_005959

UniProt Number:

P49286

Gene Name:

MTNR1B

Gene ID:

4544

Target Species:

Human

Cell Background:

CHO-K1