cAMP Hunter™ CHO-K1 MC3R Gs Cell Line

The cAMP Hunter™ CHO-K1 MC3R Gs Cell Line measures MC3R (GPCR) activity via increased levels of intracellular cAMP. This cell line ships as two vials of cryopreserved cells.

Catalog #: 95-0045C2 Size: 2 vials

Biological Information
Background Information:	The cAMP Hunter™ MC3R Gs cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. α-melanocyte stimulating hormone) based activation of MC3R GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type MC3R , a naturally Gs coupled GPCR. Upon activation of MC3R , the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	GPCR
Family:	Melanocortin Receptors
Sub Family:	Class A
Coupling:	Gs
Accession Number:	AY227893
Target Name:	MC3R
Target Aliases:	Melanocortin receptor 3MC3RMC3Melanocortin
Target Species:	Human
Cell Background:	CHO-K1

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Short term (24 h): Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	cAMP Detection
Detection Method:	Chemiluminescence

Additional Information
Brand:	cAMP Hunter™