cAMP Hunter™ CHO-K1 GRM6 Gi Cell Line

The cAMP Hunter™ CHO-K1 GRM6 Gi Cell Line measures GRM6 (GPCR) activity via increased levels of intracellular cAMP. This cell line ships as two vials of cryopreserved cells.

Catalog #: 95-0105C2 Size: 2 vials
Inquire
Biological Information
Background Information:
The cAMP Hunter™ GRM6 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. L-glutamate) based activation of GRM6 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type GRM6 , a naturally Gi/Go coupled GPCR. Upon activation of GRM6 , the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:
GPCR
Family:
Metabotropic Glutamate Receptors
Sub Family:
Class C
Coupling:
Gi/Go
Accession Number:
NM_000843
Target Name:
GRM6 (mGlu6 receptor)
Target Aliases:
Metabotropic glutamate receptor 6
Target Species:
Human
Cell Background:
CHO-K1
Usage
Product Type:
Stable Cell Lines
Application:
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage Disclaimer:
These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Functional
Assay Measures:
cAMP Detection
Detection Method:
Chemiluminescence
Additional Information
Brand:
cAMP Hunter™

User Manuals & Protocols

70-233 cAMP Hunter Gs and Gi Cell Lines REV10 User Manual

View Document

Datasheets

95-0105C2 Datasheet

View Document
AssayComplete™ Cell Plating 24 Reagent
93-0563R24A
100 mL

$339.00

AssayComplete™ Cell Detachment Reagent
92-0009
50 mL

$109.00

AssayComplete™ Cell Culture Kit-107
92-3107G
Kit

$397.00

HitHunter® cAMP Assay for Small Molecules
90-0075SM10
Inquire
AssayComplete™ Freezing Reagent F2
92-5102FR
2 x 50 mL

$339.00

AssayComplete™ Thawing Reagent T2
92-4102TR
100 mL

$249.00