cAMP Hunter™ CHO-K1 GRM3 Gi Cell Line

Background Information:

The cAMP Hunter™ GRM3 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. L-glutamate) based activation of GRM3 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type GRM3 , a naturally Gi/Go coupled GPCR. Upon activation of GRM3 , the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Glutamate (Metabotropic)

Sub Family:

Class C

Coupling:

Gi/Go

Protein Name:

mGlu3

Accession Number:

NM_000840.2

UniProt Number:

Q14832

Gene Name:

GRM3

Gene ID:

2913

Gene Aliases:

GPRC1C|mGlu3|MGLUR3

Target Species:

Human

Cell Background:

CHO-K1