cAMP Hunter™ CHO-K1 FPR1 Gi Cell Line

Background Information:

The cAMP Hunter™ FPR1 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand based activation of FPR1 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type FPR1 , a naturally Gi/Go coupled GPCR. Upon activation of FPR1 , the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Formylpeptide

Sub Family:

Class A

Coupling:

Gi/Go

Protein Name:

FPR1

Protein Aliases:

N-formyl peptide receptor|FPR|N-formylpeptide chemoattractant receptor

Accession Number:

NM_002029

UniProt Number:

P21462

Gene Name:

FPR1

Gene ID:

2357

Gene Aliases:

FPR|FMLP

Target Species:

Human

Cell Background:

CHO-K1