CaM Kinase IIalpha, active

Background Information:

CAM KINASE IIα belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene. GenBank AF091486.1

Target Class:

Kinase

Family:

CAMK

Sub Family:

Protein Ser/Thr

Protein Name:

CaMK2alpha

Protein Aliases:

CaM-kinase II alpha chain|calcium/calmodulin-dependent protein kinase II alpha-B subunit|CaM kinase II alpha subunit|CaMK-II alpha subunit|calcium/calmodulin-dependent protein kinase type II alpha chain

Accession Number:

AF091486.1

UniProt Number:

Q9UQM7

Gene Name:

CAMK2A

Gene ID:

815

Gene Aliases:

KIAA0968|CaMKIINalpha|CAMKA

Target Species:

Human