c-Kit, active

N-terminal GST-tagged recombinant, human Kit amino acids 544-end.

Catalog #: 14-559


Biological Information
Background Information:
Binding of stem cell factor (SCF) to C-Kit receptor tyrosine kinase induces homodimeriziaton and intermolecular tyrosine phosphorylation of the receptor, creating docking sites for a number of SH2-containing signal transduction molecules. These include phosphatidylinositol 3'-kinase (PI 3K) and phospholipase C-1, Stat1, the Src family kinases Src, Lyn, and Fyn, and the GTPase activating protein GAP. Mutation in Kit which result in ligand-independent activation of the kinase were found to be associated with human gastrointestinal stromal tumors and mastocytosis. GenBank X06182
Target Class:
Receptor Tyrosine Kinase
Accession Number:
NM_000222.2; NM_001093772.1
Target Name:
Target Aliases:
KIT, C-Kit, PBT, CD117, SCFR, c-kit
Target Species:
Product Type:
Drug Discovery & Development
Storage Conditions:
6 months at -70°C
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14-559x Datasheet

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