Brk, active

Background Information:

BRK (breast tumor kinase, PTK6) is a non-receptor tyrosine kinase containing SH3, SH2, and tyrosine kinase catalytic domains. BRK overexpression is frequently observed in breast cancer and several other cancer types. Studies reveal BRK translocates to membrane ruffles, where it colocalizes with paxillin during cell migration. Inhibition of BRK may be useful for the treatment of breast and other cancers. GenBank NM_005975

Target Class:

Kinase

Family:

TK

Sub Family:

Protein Tyrosine

Protein Name:

Brk (PTK6)

Protein Aliases:

Breast tumor kinase|Tyrosine-protein kinase BRK

Accession Number:

NM_005975.2

UniProt Number:

Q13882

Gene Name:

PTK6

Gene ID:

5753

Gene Aliases:

BRK

Target Species:

Human