Blk, active

N-terminal 6His-tagged recombinant, murine full length Blk.

Catalog #: 14-316


Biological Information
Background Information:
Activation of B cells by various ligands is accompanied by activation of Src-family protein tyrosine kinases. Cross-linking of the B-cell receptor leads to the activation of Src-family PTKs BLK (B-cell lymphocyte kinase), Fyn, and Lyn. Specific B and T cell progenitor subsets are preferentially susceptible to transformation by BLK and suggest a role for BLK in the control of proliferation during B cell development. BLK protein tyrosine kinase is found primarily in hematopoietic cells and inhibitors may be of therapeutic use in the treatment of B cell lymphoma. GenBank M30903. The recombinant protein contains one residue which is in conflict with M30903. This is V421Eand is reported in ESTs BF731187 and BG145526.
Target Class:
Cytosolic Tyrosine Kinase
Accession Number:
Target Name:
Target Aliases:
BLK, MGC10442
Target Species:
Product Type:
Drug Discovery & Development
Storage Conditions:
1 year at -70°C
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14-316x Datasheet

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