Blk, active

Background Information:

Activation of B cells by various ligands is accompanied by activation of Src-family protein tyrosine kinases. Cross-linking of the B-cell receptor leads to the activation of Src-family PTKs BLK (B-cell lymphocyte kinase), Fyn, and Lyn. Specific B and T cell progenitor subsets are preferentially susceptible to transformation by BLK and suggest a role for BLK in the control of proliferation during B cell development. BLK protein tyrosine kinase is found primarily in hematopoietic cells and inhibitors may be of therapeutic use in the treatment of B cell lymphoma. GenBank M30903. The recombinant protein contains one residue which is in conflict with M30903. This is V421Eand is reported in ESTs BF731187 and BG145526.

Target Class:

Kinase

Family:

TK

Sub Family:

Protein Tyrosine

Protein Name:

BLK

Protein Aliases:

B lymphocyte kinase|p55-Blk

Accession Number:

M30903.1

UniProt Number:

P16277

Gene Name:

Blk

Gene ID:

12143

Gene Aliases:

0

Target Species:

Mouse