Biological Information | |
---|---|
Background Information: | Activation of B cells by various ligands is accompanied by activation of Src-family protein tyrosine kinases. Cross-linking of the B-cell receptor leads to the activation of Src-family PTKs BLK (B-cell lymphocyte kinase), Fyn, and Lyn. Specific B and T cell progenitor subsets are preferentially susceptible to transformation by BLK and suggest a role for BLK in the control of proliferation during B cell development. BLK protein tyrosine kinase is found primarily in hematopoietic cells and inhibitors may be of therapeutic use in the treatment of B cell lymphoma.
GenBank NM_001715. The recombinant protein contains one residue which is in conflict with NM_001715. This is M287V and is reported in GenBank S76617 and BC007371. |
Target Class: | Kinase |
Family: | Cytosolic Tyrosine Kinase |
Accession Number: | NM_001715.2 |
Target Name: | Blk |
Target Aliases: | BLK, MGC10442 |
Target Species: | Human |
Usage | |
Product Type: | Enzymes |
Application: | Drug Discovery & Development |
Storage Conditions: | 6 months at -70°C |
Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
Datasheets
14-517x Datasheet
View Document