This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
BMP2K, BMP2 Inducible Kinase, BMP-2-Inducible Protein Kinase, EC 220.127.116.11, HRIHFB201
Drug Discovery & Development
1 year at -70°C
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10 µg of active BIKe. N-terminal 6His-tagged, recombinant fragment of human BIKe.