Biological Information | |
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Background Information: | B-RAF plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes.
GenBank NM_004333 |
Target Class: | Kinase |
Family: | Ser/Thr Kinase |
Accession Number: | NM_004333.3 |
Target Name: | B-Raf |
Target Aliases: | BRAF, BRAF1, B-Raf, MGC126806, RAFB1, p94, MGC138284, B-raf-1 |
Target Species: | Human |
Usage | |
Product Type: | Enzymes |
Application: | Drug Discovery & Development |
Storage Conditions: | 6 months at -70°C |
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