Axl, active

Background Information:

AXL is a member of AXL protein-tyrosine kinase family and expressed human myeloid leukemia cells. Gas6, the protein product of the growth arrest-specific gene 6 (gas6), a member of the vitamin K-dependent protein family, was identified as a ligand for the Axl/Sky family of receptor tyrosine kinases. Gas6/Axl signaling has been related to the cell growth and protection from apoptosis in normal and cancer cells. GenBank NM_021913. The recombinant protein also contains the conflict Q764R with respect to GenBank NM_021913. This substitution is reported in GenBank BC032229. The residue coordinates in the native sequence are given.

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

AXL

Protein Aliases:

AXL oncogene

Accession Number:

NM_001699.3; NM_021913.2

UniProt Number:

P30530

Gene Name:

AXL

Gene ID:

558

Gene Aliases:

UFO|JTK11|Tyro7|ARK

Target Species:

Human