| Biological Information | |
|---|---|
| Background Information: | Protein serine/threonine kinase Aurora-A (STK6, STK15, BTAK, AIK, ARK1, AURA, Aurora-related kinase 1, Breast-tumor-amplified kinase) is one of a family of serine-threonine kinases that have been strongly linked to chromosome segregation and centrosome functions. There are three isoforms of Aurora kinase: A, B, and C. Molecular mechanism of Aurora-A regulation of G2-M transition is phosphorylation of histone H3. Inhibition of Aurora A may be useful in the treatment of many types of human cancer, including leukemia, colon and breast cancer.
GenBank NM_003600. The recombinant protein also contains the conflict I31F with respect to GenBank NM_003600. This substitution is reported in GenBank NM_003158 and BC027464. The residue coordinates in the native sequence are given. |
| Target Class: | Kinase |
| Accession Number: | GenBank NM_003600 |
| Target Name: | Aurora-A |
| Target Aliases: | AURKA, STK7, AURA, AIK, hARK1, BTAK, AURORA2, aurora-A, Aurora-A, STK15, AurA, ARK1, MGC34538, STK6 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
Aurora A, active
N-terminal 6His-tagged recombinant, human full length Aurora A.
Datasheets
14-511x Datasheet
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