ARK5 (AMPK related kinase 5) is a serine/threonine kinase and a member of the AMPK family of protein kinases. In response to stimulation by Akt, ARK5 prevents cell death induced by glucose starvation and death receptor activation in tumor cells as a result of inhibition of caspase 8 activation via preservation of c-FLIP. ARK5 can also negatively regulate procaspase-6 via direct phosphorylation at Ser257, leading to resistance to the FasL/Fas signaling system. GenBank NM_014840
Drug Discovery & Development
6 months at -70°C
These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.