| Biological Information | |
|---|---|
| Background Information: | CD80 is a costimulatory molecule known for its role in T-cell activation and also in regulating the activity of normal and malignant B cells. Surface CD80 is expressed transiently on activated B cells, macrophages, and DCs. Surprisingly, CD80 is downregulated on most of the cancer cells, and the loss of CD80 alone is sufficient to allow them to escape the attack of the immune system and to impart anergy and apoptosis in tumor-infiltrating T cells. |
| Family: | IgSF (immune inhibitory Receptor ligand) |
| Target Name: | mCD80 |
| Usage | |
| Product Type: | Antibodies |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 4°C. Please avoid multiple freeze/thaw cycles. |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
| Additional Information | |
| Brand: | DiscoverX |
Anti-mCD80 Monoclonal Antibody
The monoclonal antibody recognizes mouse CD80, a ~55 kDa cell surface glycoprotein. CD80 (also known as B7-1, B7, and BB1) is expressed on monocytes, macrophages, and dendritic cells in mice.
Datasheets
92-1360 Datasheet
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