Biological Information
Background Information:
CD80 is a costimulatory molecule known for its role in T-cell activation and also in regulating the activity of normal and malignant B cells. Surface CD80 is expressed transiently on activated B cells, macrophages, and DCs. Surprisingly, CD80 is downregulated on most of the cancer cells, and the loss of CD80 alone is sufficient to allow them to escape the attack of the immune system and to impart anergy and apoptosis in tumor-infiltrating T cells.
Target Class:
Checkpoint Receptor
Family:
IgSF
Sub Family:
Immune Inhibitory Receptor Ligand
Usage
Product Type:
Antibodies
Application:
Drug Discovery & Development
Storage Conditions:
4°C. Please avoid multiple freeze/thaw cycles.
Usage disclaimer:
These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Additional Information
Brand:
Eurofins DiscoverX®