| Biological Information | |
|---|---|
| Background Information: | Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.
GenBank NM_001105 |
| Target Class: | Kinase |
| Family: | Receptor Tyrosine Kinase (RTK): Type XIX RTK: Leukocyte tyrosine kinase (LTK) Receptor family |
| Accession Number: | NM_001105 |
| Target Name: | ALK2 |
| Target Aliases: | ACVR1, SKR1, FOP, ACTRI, TSRI |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
ALK2, active
10 µg of active ALK2. N-terminal 6His-tagged recombinant, human ALK2 amino acids 147-end.
Datasheets
14-937x Datasheet
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