| Biological Information | |
|---|---|
| Background Information: | ALK or anaplastic lymphoma kinase (Ki-1) is a membrane-spanning tyrosine kinase receptor that is most closely related to leukocyte tyrosine kinase. No function has been ascribed for ALK; however, its restricted expression in neural tissue suggests that this receptor might play an important role in the normal development and function of the nervous system. Large-cell anaplastic lymphoma is a subtype of non-Hodgkin's lymphoma. Over half of these lymphomas have a chromosomal translocation t(2;5), that leads to the expression of a hybrid protein comprised of the nucleolar phosphoprotein nucleophosmin (NPM) and ALK.
GenBank U62540 |
| Target Class: | Kinase |
| Family: | Receptor Tyrosine Kinase (RTK): Type XIX RTK: Leukocyte tyrosine kinase (LTK) Receptor family |
| Accession Number: | NM_004304.3 |
| Target Name: | ALK |
| Target Aliases: | ALKCD246TFG/ALK |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
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Alk, active
N-terminal 6His-tagged recombinant, human ALK, amino acids 1058-end.
Datasheets
14-555x Datasheet
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