Biological Information

Background Information:

AKT (also called protein kinase B) is a serine/threonine protein kinase that has been implicated in mediating a variety of biological responses including inhibiting apoptosis and stimulating cellular growth. Three mammalian isoforms (AKT1, AKT2, and AKT3) of the kinase have been identified. EMBL AF124141. The recombinant protein contains an amino acid substitution, S472D, with reference to EMBL AF124141. This mutation mimics phosphorylation of S472.

Target Class:

Kinase

Family:

AGC

Sub Family:

Protein Ser/Thr

Protein Name:

Akt3 (PKBgamma)

Protein Aliases:

protein kinase B, gamma

Accession Number:

NM_005465.3; NM_181690.1

UniProt Number:

Q9Y243

Gene Name:

AKT3

Gene ID:

10000

Gene Aliases:

PKBG|RAC-gamma|PRKBG

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

6 months at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology