Akt2/PKBbeta (deltaPH, S474D), active

Background Information:

Akt2, also known as Protein Kinase B Beta, is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains, which is involved in signaling pathways. Akt2 serves as an oncogene in the tumorigenesis of cancer cells For example, its overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phosphorylating several known proteins, and has also been implicated in insulin signaling. EMBL M95936. The recombinant protein contains an amino acid substitution, S474D, with reference to the native sequence. This mimics the phosphorylation of S474.

Target Class:

Kinase

Family:

AGC

Sub Family:

Protein Ser/Thr

Protein Name:

Akt2 (PKBbeta)

Protein Aliases:

Protein kinase Akt-2|Protein kinase B beta|PKB beta|RAC-PK-beta

Accession Number:

NM_001626.3

UniProt Number:

P31751

Gene Name:

AKT2

Gene ID:

208

Target Species:

Human