Abl (Q252H), active

Background Information:

N-terminal 6His-tagged recombinant, human Abl, amino acids 27-end containing the Q252H mutation. The Abl tyrosine kinase inhibitor STI571 is an effective therapy for stable-phase chronic myeloid leukemia patients. Many patients responding to STI571 later relapse due to a reactivation of Bcr-Abl activity. In certain cases this appears to correlate with the presence of the Q252H mutation, which confers resistance to drug binding (Shah et al., (2002), Cancer Cell 2, 117-125).

Target Class:

Kinase

Family:

TK

Sub Family:

Protein Tyrosine

Protein Name:

Abl

Protein Aliases:

Abelson murine leukemia viral oncogene homolog 1|Abelson tyrosine-protein kinase 1|Proto-oncogene c-Abl|p150

Accession Number:

NM_005157.3; NM_007313.2

UniProt Number:

P00519

Gene Name:

ABL1

Gene ID:

25

Gene Aliases:

JTK7|c-ABL|p150

Target Species:

Human