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eXpress™ Assay Kits
Discovery Phase Cell-Based Assays for Determining Proof-of-concept, MOA Confirmation, & Rank-ordering Studies
eXpress Assay kits developed by Eurofins DiscoverX® are ready-to-use (RTU), highly sensitive cell-based assay kits for quick analysis and quantitative results. These kits are designed for functional mechanism of action (MOA) and binding assays for drug discovery target validation, screening and hit ID, and lead optimization applications.
What Is Included in Each eXpress Assay Kit
Each assay kit includes RTU cryopreserved cells, optimized assay reagents, plates, and a detailed, homogeneous (no wash) assay protocol to ensure robust, reproducible performance every time with minimal hands-on steps. By eliminating lengthy, time-consuming, and expensive cell culture steps, eXpress assay kits enable you to screen your small molecule or biologic therapeutics and generate accurate, precise, and reproducible data in just a few hours.
Eurofins DiscoverX offers over 1,000 target-specific eXpress assay kits for a broad range of target classes, including GPCRs, kinases, cytokine/interleukin receptors, immune checkpoint receptors, nuclear hormone receptors (NHRs), epigenetic proteins, and more. The homogeneous assay kit format allows you to detect agonists, antagonists, and allosteric modulators. Their chemiluminescent read-outs can be read on any standard benchtop luminometer to provide fast and reliable results. Simply thaw, plate, and run the assay! Minimize assay development time and eliminate the need for cell culture.
eXpress Assay Kits are automation friendly and intended for in vitro research use only. These kits are not suitable for lot release applications. Refer to the bioassay format for potency testing in lot release for biologic therapeutics.
Product Highlights
- Target Characterization - Identify targets and validate distinguishing target-specific variations like species, orthologs, isotype, and more during early drug discovery programs
- Functional and Binding Analysis - Perform quick, high-throughput cell-based assay binding and mechanism-of-action (MOA) assessment of your small molecule compounds or biologics
- Screening and Hit Identification - Identify hits; run primary, secondary and orthogonal screens; and rank-order hits
- Lead Optimization - Define best leads; optimize lead potencies, efficacy, and specificity; and perform SAR and ligand bias studies
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Product Types
- All eXpress Assay Kits – Quick analysis eXpress assay kits are based on the Eurofins DiscoverX Enzyme Fragment Complementation (EFC) platform, are available in 96-well 2-plate and 10-plate kits formats, and includes cells, optimized reagents, and plates for convenience.
- InCELL Hunter™ eXpress Kits – Determine compound entry and target engagement (binding) to intracellular kinase and epigenetic protein targets. Learn about InCELL target engagement products.
- GPCR eXpress Kits – Assess GPCR recruitment of β-arrestin, accumulation of cAMP, or internalization of GPCRs. Learn more about GPCR product solutions.
- Checkpoint Receptor eXpress Kits – Analyze dimerization of TIM3/TIM3 and VISTA/VISTA checkpoint receptors. Learn more about Checkpoint Receptor Products.
- Cytokine Receptor eXpress Kits – Determine receptor activation (SH2-recruitment) and dimerization assessment of several cytokines and interleukin receptors. Learn more about Cytokine Receptor Products.
- Kinase eXpress Kits – Assess intracellular kinase compound entry and target engagement (binding) and receptor tyrosine kinase (RTK) activation (SH2-recruitment)). Learn more about Kinase Product Solutions.
- SPRINTer™ eXpress Kits – Targeted protein degradation assays to rapidly detect protein turnover induced by targeted protein degrader molecules. Learn more about SPRINTer Targeted protein degradation assays.