20 New Assays Just Launched

Kinase Screening and Profiling Services

The fastest kinase profiling services just got bigger and better!

DiscoveRx’s KINOMEscan® service provides the industry’s fastest and most comprehensive kinase inhibitor testing. DiscoveRx is also the highest rated provider of kinase testing and offers options to profile compounds using a broad panel of 489 assays. Investigators can also profile compounds across small custom selectivity panels, conduct dose response curves to measure inhibitor potency, or screen 100 to 1,000,000 compounds against a single target. With the broadest assay menu and fastest cycle time, KINOMEscan has been helping Pharmaceutical, Biotech, and Academic institutions to advance their drug discovery programs since 2004


New Kinase Assay Panel Highlights
 

  • Twenty new assays added to the KdELECT® panels
  • Eleven clinically relevant mutants
  • Several unique assays available include CDK10, CDK12, CDK20, MLKL and MLKL (full length), IRAK2 and others

 

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489 Kinase Assays

New Kinase Assays

DiscoveRx Gene Symbol

Entrez Gene Symbol

Kinase Name

Kinase Group

Clinical Relevance

ALK(1151Tins) ALK anaplastic lymphoma receptor tyrosine kinase TK Crizotinib Resistance in Non Small Cell Lung Cancer
ALK(F1174L) ALK anaplastic lymphoma receptor tyrosine kinase TK Crizotinib Resistance in Inflammatory Myofibroblastic Tumors
CDK20 CDK20 cyclin-dependent kinase 20 [ Homo sapiens (human) ] CMGC  
CDK6 CDK6 cyclin-dependent kinase 6 [ Homo sapiens (human) ] CMGC Validated Target in Breast Cancer
DDR2(T654M) DDR2 discoidin domain receptor tyrosine kinase 2 TK Gatekeeper mutation Confers Dasatinib Resistance
ERK1(Q122L) MAPK3 mitogen-activated protein kinase 3 CMGC Bulky ERK1 Gatekeeper Mutation
IRAK2 IRAK2 interleukin-1 receptor-associated kinase 2 [ Homo sapiens (human) ] TKL  
MLKL MLKL mixed lineage kinase domain-like protein isoform 1 [Homo sapiens] TKL Inflammatory and Necroptosis
MLKL(full-length) MLKL mixed lineage kinase domain-like protein isoform 1 [Homo sapiens] TKL Inflammatory and Necroptosis
PKAC-alpha(L206R) PRKACA cAMP-dependent protein kinase catalytic subunit alpha isoform Calpha1 [Homo sapiens] AGC Mutation found in more than 50% of Cushing’s Syndrome cases with Adrenocortical Adenomas
CDK1 CDK1 cyclin-dependent kinase 1 [ Homo sapiens (human) ] CMGC  
CDK10 CDK10 cyclin-dependent kinase 10 [ Homo sapiens (human) ] CMGC Tumor Suppressor and Biliary Tract Cancer
CDK12 CDK12 cyclin-dependent kinase 12 isoform 2 [Homo sapiens] CMGC Ovarian Carcinoma
PASK PASK PAS domain containing serine/threonine kinase [ Homo sapiens (human) ] CAMK Metabolic Disease
CDK4-cyclinD1(F93L) CDK4 cyclin-dependent kinase 4 CMGC Bulky CDK4 Gatekeeper Mutation
FGFR2(N550K) FGFR2 fibroblast growth factor receptor 2 TK Activating and Dovitinib-Resistance Mutation of Molecular Brake
FGFR3(V555M) FGFR3 fibroblast growth factor receptor 3 TK Gatekeeper Mutation Confers Drug Resistance
FGFR3(K650E) FGFR3 fibroblast growth factor receptor 3 TK Relapsed Multiple Myeloma
RET(A883F) RET ret proto-oncogene TK Multiple  Endocrine Neoplasia Type 2B
RET(V804E) RET ret proto-oncogene TK Gatekeeper Mutation that Confers Vandetanib Resistance