DiscoveRx Gene Symbol
|
Entrez Gene Symbol
|
Kinase Name
|
Kinase Group
|
Clinical Relevance
|
ALK(1151Tins) |
ALK |
anaplastic lymphoma receptor tyrosine kinase |
TK |
Crizotinib Resistance in Non Small Cell Lung Cancer |
ALK(F1174L) |
ALK |
anaplastic lymphoma receptor tyrosine kinase |
TK |
Crizotinib Resistance in Inflammatory Myofibroblastic Tumors |
CDK20 |
CDK20 |
cyclin-dependent kinase 20 [ Homo sapiens (human) ] |
CMGC |
|
CDK6 |
CDK6 |
cyclin-dependent kinase 6 [ Homo sapiens (human) ] |
CMGC |
Validated Target in Breast Cancer |
DDR2(T654M) |
DDR2 |
discoidin domain receptor tyrosine kinase 2 |
TK |
Gatekeeper mutation Confers Dasatinib Resistance |
ERK1(Q122L) |
MAPK3 |
mitogen-activated protein kinase 3 |
CMGC |
Bulky ERK1 Gatekeeper Mutation |
IRAK2 |
IRAK2 |
interleukin-1 receptor-associated kinase 2 [ Homo sapiens (human) ] |
TKL |
|
MLKL |
MLKL |
mixed lineage kinase domain-like protein isoform 1 [Homo sapiens] |
TKL |
Inflammatory and Necroptosis |
MLKL(full-length) |
MLKL |
mixed lineage kinase domain-like protein isoform 1 [Homo sapiens] |
TKL |
Inflammatory and Necroptosis |
PKAC-alpha(L206R) |
PRKACA |
cAMP-dependent protein kinase catalytic subunit alpha isoform Calpha1 [Homo sapiens] |
AGC |
Mutation found in more than 50% of Cushing’s Syndrome cases with Adrenocortical Adenomas |
CDK1 |
CDK1 |
cyclin-dependent kinase 1 [ Homo sapiens (human) ] |
CMGC |
|
CDK10 |
CDK10 |
cyclin-dependent kinase 10 [ Homo sapiens (human) ] |
CMGC |
Tumor Suppressor and Biliary Tract Cancer |
CDK12 |
CDK12 |
cyclin-dependent kinase 12 isoform 2 [Homo sapiens] |
CMGC |
Ovarian Carcinoma |
PASK |
PASK |
PAS domain containing serine/threonine kinase [ Homo sapiens (human) ] |
CAMK |
Metabolic Disease |
CDK4-cyclinD1(F93L) |
CDK4 |
cyclin-dependent kinase 4 |
CMGC |
Bulky CDK4 Gatekeeper Mutation |
FGFR2(N550K) |
FGFR2 |
fibroblast growth factor receptor 2 |
TK |
Activating and Dovitinib-Resistance Mutation of Molecular Brake |
FGFR3(V555M) |
FGFR3 |
fibroblast growth factor receptor 3 |
TK |
Gatekeeper Mutation Confers Drug Resistance |
FGFR3(K650E) |
FGFR3 |
fibroblast growth factor receptor 3 |
TK |
Relapsed Multiple Myeloma |
RET(A883F) |
RET |
ret proto-oncogene |
TK |
Multiple Endocrine Neoplasia Type 2B |
RET(V804E) |
RET |
ret proto-oncogene |
TK |
Gatekeeper Mutation that Confers Vandetanib Resistance |