New GPCR White Paper

GPCR Functional ‘Volume Control’ in Cell Systems:

Tuning Receptor Density & System Sensitivity to Define Compound Activity

Obtain the latest GPCR white paper on approaches to study drug effects in functional systems where ‘volume control’ techniques are used to reveal candidate profiles that are likely to emerge in therapeutic in vivo systems.

  • How volume control of functional systems can be used to quantitatively measure the relative affinity & efficacy of agonists, with examples of using inducible cell lines
  • How to turn agonists into antagonists & bring out hidden efficacies of antagonists
  • How to characterize allosteric molecules with respect to affinity & efficacy

This white paper was written by GPCR expert Terry Kenakin, Ph.D., Professor of Pharmacology, University of North Carolina School of Medicine, in collaboration with Eurofins DiscoverX.

GPCR Functional ‘Volume Control’ in Cell Systems

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