ZAP-70, active

Background Information:

ZA70 (Tyrosine Protein kinase ZAP-70, 70 kDa zeta-associated protein, Syk-related tyrosine kinase) is a cytosolic protein tyrosine kinase (PTK) and a member of the Syk family of proteins. ZA70 is expressed in human and murine thymocyte subsets, B cells, and peripheral T cell subsets and associates with zeta-chain to undergo tyrosine phosphorylation following TCR stimulation. ZA70 inhibitors may be useful as immunosuppressants. GenBank L05148

Target Class:

Kinase

Family:

TK

Sub Family:

Protein Tyrosine

Protein Name:

ZAP70

Protein Aliases:

tyrosine-protein kinase ZAP-70

Accession Number:

NM_001079.3; NM_207519.1

UniProt Number:

P43403

Gene Name:

ZAP70

Gene ID:

7535

Gene Aliases:

ZAP-70|STD

Target Species:

Human