Biological Information

Background Information:

WRN is a member of the RecQ Helicase family that incudes RECQ1, BLM, RECQ4 and RECQ5. Mutations in WRN can lead to Werner syndrome, characterized by premature ageing and cancer predisposition. It is a multifunctional enzyme with helicase and exonuclease activities and plays roles in various cellular processes important for the maintenance of genome stability, including DNA replication, transcription, DNA repair, and telomere maintenance. Recent studies have identified WRN as a potent and selective vulnerability of microsatellite instability-high cancers.

Target Class:

Helicase

Family:

RecQ

Sub Family:

DNA helicase

Protein Aliases:

RECQ3, RECQL2

Accession Number:

NM_000553.6

UniProt Number:

Q14191

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Oncology