Biological Information
Background Information:
Wortmannin is a natural product that potently inhibits PI3K with anti-inflammatory and immunosuppressant effects in vivo. It has been used extensively in the study of insulin-regulated events in a variety of cells. It was also used to study the activation of PI3K by other growth factors, such as platelet-derived growth factor. Wortmannin was reported to block insulin-stimulated expression of lipogenic genes, such as Srebp-1c and Acc. It also blocked insulin-stimulated glycogen synthase, S6K, Akt, and GSK-3 activities. Interestingly, it has been reported that Wortmannin also inhibited the activity of smooth muscle myosin light-chain kinase. (Modern Methods in Natural Products Chemistry, 9.17.3.3.4 Wortmannin, 2010)
Usage
Product Type:
Control Ligands & Inhibitors
Application:
Drug Discovery & Development
Storage Conditions:
Store at ≤-20°C. Please avoid multiple freeze/thaw cycles.
Usage disclaimer:
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Additional Information
Brand:
Eurofins DiscoverX®