WNK2, active

Background Information:

WNK2 (WNK Lysine Deficient Protein Kinase 2) is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. WNK2 plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity. GenBank NM_006648

Target Class:

Kinase

Family:

Other Protein Kinase

Sub Family:

Protein Ser/Thr

Protein Name:

WNK2

Protein Aliases:

Antigen NY-CO-43|Protein kinase lysine-deficient 2|Protein kinase with no lysine 2|Serologically defined colon cancer antigen 43

Accession Number:

NM_006648.3

UniProt Number:

Q9Y3S1

Gene Name:

WNK2

Gene ID:

65268

Gene Aliases:

NY-CO-43|KIAA1760

Target Species:

Human